|
KMID : 0377220010260010059
|
|
Medical Journal of Chosun Univercity
2001 Volume.26 No. 1 p.59 ~ p.63
|
|
|
Immunohistochemical Expression of p27 in Epithelial Tumor
|
|
Lee Myung-Ki
Chung Byoung-Soo
|
|
|
Abstract
|
|
|
Background and objectives: p27 belong to the family of cyclin dependent kinase inhibitors, which are important negative regulators of the cell cycle. Loss of normal cell cycle regulation contributes to the development and progression of tumors. Although p27 may play role in tumor progression, the precise function and expressive pattern in epithlial tumors are less clear. The propose of this study was to investigated the expressive patterns of p27 in benign, precancerous and malignant epithelial tumors.
Materials and Methods: Formalin-Fixed and paraffin-embedded tissue from 5 seborrheic keratosis, 5 actinic keratosis, 5 Bowen disease, 7 basal cell carcinoma, 13 squamous cell carcinoma were immunolabeled with monoclonal antibodies directed p27.
Results: The seborrheic keratosis showed a very low expression of p27 in all cases. In two cases of actinic keratosis, p27 staining was observed in dysplastic cells that proliferative into dermis. The Bowen’s disease showed low expression of p27 except dyskeratotic cells. The basal cell carcinoma showed positive staininng in central portion of tumor lobules on 4 cases. The low expression of p27 staining was observed well-differentiated squamous cell carcinoma except dyskeratotic cells and horn pearls, but poory-differentiated squamous cell carcinoma showed moderate expression in 2 cases and high expression in 2 cases.
Conclusion: These result represent that the decresae of p27 might related to tumorigenesis, and p27 expression might reflect the terminal differentiation of tumor cells.
|
|
|
KEYWORD
|
|
|
p27, Cell Cycle, Tumorigenesis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|